Ulcerative Colitis with Positivity for Proteinase 3-Antineutrophil Cytoplasmic Antibody

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Ulcerative colitis with positivity for proteinase 3-antineutrophil cytoplasmic antibody.

ANCA) and the perinuclear (P-ANCA). CANCA appears as a granular, diffuse cytoplasmic fluorescence, often with accentuated fluorescence around the nuclear lobes, and typical P-ANCA reactivity is Dear Sir, A 33-year-old woman was admitted to our hospital with cough and fever (over 39.0 ° C). About 1 month prior to the current admission, she had presented with fever (over 39.0 ° C), diarrhea and b...

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Proteinase 3-antineutrophil cytoplasmic antibody-positive ulcerative colitis presenting with abducens neuropathy

A 72-year-old man with ulcerative colitis (UC) presented with complete left abducens nerve palsy. Although MRI showed no significant changes, cerebrospinal fluid analysis revealed pleocytosis and elevated protein and interleukin (IL)-6 levels. His serum proteinase 3-antineutrophil cytoplasmic antibody (PR3-ANCA) level was also elevated to 31.1 U/mL, but granulomatosis with polyangiitis was not ...

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antineutrophil cytoplasmic autoantibodies in ulcerative colitis

antineutrophil cytoplasmic autoanibodies (anca) were detecte in patients with certain autoimmune vascular disease such as wegner’s granulomatosis, polyarthrits nodosa and systemic luuc erythematous. indirect immunofluorescence (iif) technique was employed to detec these autoantibodies.anca have been recently detected in some forms of inflammatory bowel disease (ibd), ulcerative colitis (u.c). c...

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Clinical Outcomes of Patients with Dual Positivity for Proteinase 3 and Myeloperoxidase Specific Antineutrophil Cytoplasmic Antibodies

Objective: Granulomatous polyangiitis patients generally have ANCA targeting Proteinase 3 (PR3), while microscopic polyangiitis and eosinophilic granulomatous polyangiitis patients generally have ANCA targeting myeloperoxidase (MPO). Patients positive for both PR3-ANCA and MPO-ANCA are uncommon and any diagnostic value of this situation has not been well described. The aim of this study was to ...

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Antineutrophil cytoplasmic antibody positivity in IgG4-related disease

BACKGROUND IgG4-related disease (IgG4-RD) is a fibroinflammatory condition characterized by serum IgG4 elevation and tissue infiltration of IgG4-positive plasma cells. Substantial overlap between IgG4-RD and antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitides (AAV) exists in terms of organ involvement and histopathological features. A positive ANCA assay is regarded as a highly...

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ژورنال

عنوان ژورنال: Digestion

سال: 2008

ISSN: 0012-2823,1421-9867

DOI: 10.1159/000140976